Carter (Thomas Jane), a troubled veteran who gets a chance at redemption by protecting a 12 year-old girl from an assassin after she witnesses a murder. Holding a shotgun with a single shell, he engages in physical and psychological warfare in a desperate fight for the girl's life.
Two New Orleans detectives become embroiled in a centuries-long feud between two secretive factions of vampires while investigating a runaway child's case. Torn between their everyday lives and the dangerous lure of immortality, the detectives must race to destroy the evil Moldero clan.